A rhodamine-deoxylactam based sensor for chromo-fluorogenic detection of nerve agent simulant.
نویسندگان
چکیده
N-(rhodamine B)-deoxylactam-5-amino-1-pentanol (dRB-APOH) was designed and prepared as the chromo-fluorogenic sensor for detection of a nerve agent simulant via analyte triggered tandem phosphorylation and opening of the intramolecular deoxylactam. The successful detection of diethyl chlorophosphate suggests the utility of rhodamine-deoxylactams as the chromo-fluorogenic signal reporting platform for design of sensors targeting reactive chemical species via various chemistries.
منابع مشابه
Chromogenic and fluorogenic detection of a nerve agent simulant with a rhodamine-deoxylactam based sensor.
A chromogenic and fluorogenic detection of a nerve agent simulant was developed based on diethyl chlorophosphate triggered tandem phosphorylation and intramolecular cyclization of N-(rhodamine B)-deoxylactam-2-aminoethanol.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 22 20 شماره
صفحات -
تاریخ انتشار 2012